Drug interactions
Azithromycin + Indacaterol-glycopyrronium
Severity: Moderate
Azithromycin and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azithromycin can prolong the QT interval, and long-acting beta-agonists such as indacaterol may add to the cardiac repolarization effects at high exposure. Together they may modestly raise the risk of ventricular arrhythmia, especially in patients with other risk factors.
What this interaction means in plain words
Azithromycin and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization (QT prolongation) and beta-adrenergic cardiac stimulation.
What to do
Check baseline QTc and correct hypokalemia and hypomagnesemia in patients with cardiac risk factors. Consider ECG monitoring if other QT-prolonging drugs are used, or choose a non-macrolide antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Azithromycin and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azithromycin can prolong the QT interval, and long-acting beta-agonists such as indacaterol may add to the cardiac repolarization effects at high exposure. Together they may modestly raise the risk of ventricular arrhythmia, especially in patients with other risk factors.
How serious is the interaction between Azithromycin and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline QTc and correct hypokalemia and hypomagnesemia in patients with cardiac risk factors. Consider ECG monitoring if other QT-prolonging drugs are used, or choose a non-macrolide antibiotic.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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