Drug interactions
Azithromycin + Osilodrostat
Severity: Moderate
Azithromycin and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat can prolong the QT interval, as can azithromycin. The combination may increase the risk of torsades de pointes, particularly if cortisol suppression causes electrolyte shifts.
What this interaction means in plain words
Azithromycin and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Osilodrostat belongs to Endocrine.
Why it happens
Additive QT prolongation.
What to do
Check ECG and potassium and magnesium before and during therapy. Consider an alternative antibiotic when QT risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Azithromycin with Osilodrostat?
MediHelp rates the interaction as moderate. Azithromycin and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat can prolong the QT interval, as can azithromycin. The combination may increase the risk of torsades de pointes, particularly if cortisol suppression causes electrolyte shifts.
How serious is the interaction between Azithromycin and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and potassium and magnesium before and during therapy. Consider an alternative antibiotic when QT risk is high.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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