Drug interactions
Azithromycin + Osimertinib
Severity: Moderate
Azithromycin and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib is associated with QTc prolongation, and azithromycin adds to this effect. Combined use may raise the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Azithromycin and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Osimertinib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Perform periodic ECG and electrolyte monitoring during co-therapy. Prefer a non-QT-prolonging antibiotic if the QTc is already elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Azithromycin with Osimertinib?
MediHelp rates the interaction as moderate. Azithromycin and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib is associated with QTc prolongation, and azithromycin adds to this effect. Combined use may raise the risk of serious ventricular arrhythmia.
How serious is the interaction between Azithromycin and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform periodic ECG and electrolyte monitoring during co-therapy. Prefer a non-QT-prolonging antibiotic if the QTc is already elevated.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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