Drug interactions
Azithromycin + Paliperidone
Severity: Moderate
Azithromycin and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone has a recognized dose-related effect on the QT interval, and azithromycin may add to it. The combination can increase the risk of ventricular arrhythmias in susceptible patients.
What this interaction means in plain words
Azithromycin and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Paliperidone belongs to Central Nervous System.
Why it happens
Additive QTc prolongation through cardiac potassium channel inhibition.
What to do
Obtain a baseline ECG and correct hypokalemia and hypomagnesemia before combining. Consider an alternative antibiotic in patients with known QT prolongation or other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Azithromycin with Paliperidone?
MediHelp rates the interaction as moderate. Azithromycin and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone has a recognized dose-related effect on the QT interval, and azithromycin may add to it. The combination can increase the risk of ventricular arrhythmias in susceptible patients.
How serious is the interaction between Azithromycin and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct hypokalemia and hypomagnesemia before combining. Consider an alternative antibiotic in patients with known QT prolongation or other risk factors.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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