Drug interactions
Azithromycin + Pomalidomide
Severity: Minor
Azithromycin and Pomalidomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pomalidomide is a P-glycoprotein substrate and azithromycin is a weak P-glycoprotein inhibitor. Any increase in pomalidomide exposure is expected to be small and of limited clinical importance.
What this interaction means in plain words
Azithromycin and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azithromycin belongs to Anti Bacterial; Pomalidomide belongs to Miscellaneous.
Why it happens
Possible weak inhibition of P-glycoprotein efflux of pomalidomide by azithromycin.
What to do
No dose change is generally needed; monitor for pomalidomide adverse effects such as neutropenia and fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Azithromycin with Pomalidomide?
MediHelp rates the interaction as minor. Azithromycin and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pomalidomide is a P-glycoprotein substrate and azithromycin is a weak P-glycoprotein inhibitor. Any increase in pomalidomide exposure is expected to be small and of limited clinical importance.
How serious is the interaction between Azithromycin and Pomalidomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for pomalidomide adverse effects such as neutropenia and fatigue.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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