Drug interactions
Azithromycin + Rimegepant
Severity: Moderate
Azithromycin and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rimegepant is a P-glycoprotein substrate, and azithromycin may inhibit this transporter, which could modestly raise rimegepant exposure. The clinical effect is likely small, as azithromycin is a weak P-gp inhibitor.
What this interaction means in plain words
Azithromycin and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Rimegepant belongs to Central Nervous System.
Why it happens
Inhibition of P-glycoprotein efflux by azithromycin may increase rimegepant absorption and exposure.
What to do
Avoid taking a second rimegepant dose within 48 hours when used with P-gp inhibitors, per labeling. Monitor for adverse effects such as nausea.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Azithromycin with Rimegepant?
MediHelp rates the interaction as moderate. Azithromycin and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rimegepant is a P-glycoprotein substrate, and azithromycin may inhibit this transporter, which could modestly raise rimegepant exposure. The clinical effect is likely small, as azithromycin is a weak P-gp inhibitor.
How serious is the interaction between Azithromycin and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking a second rimegepant dose within 48 hours when used with P-gp inhibitors, per labeling. Monitor for adverse effects such as nausea.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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