Drug interactions
Azithromycin + Solifenacin
Severity: Moderate
Azithromycin and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT interval prolongation, and solifenacin has a dose-related QT effect at supratherapeutic doses. Combined use may add to arrhythmia risk, especially with electrolyte disturbances, bradycardia or underlying heart disease.
What this interaction means in plain words
Azithromycin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Solifenacin belongs to Genitourinary.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Correct potassium and magnesium before starting and consider an ECG in patients with other QT risk factors. Choose an alternative antibiotic if the patient has known QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Solifenacin?
MediHelp rates the interaction as moderate. Azithromycin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT interval prolongation, and solifenacin has a dose-related QT effect at supratherapeutic doses. Combined use may add to arrhythmia risk, especially with electrolyte disturbances, bradycardia or underlying heart disease.
How serious is the interaction between Azithromycin and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before starting and consider an ECG in patients with other QT risk factors. Choose an alternative antibiotic if the patient has known QT prolongation.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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