Drug interactions
Azithromycin + Vorinostat
Severity: Moderate
Azithromycin and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat and azithromycin can each prolong the QT interval, so combination may increase the risk of serious ventricular arrhythmia, especially in patients with electrolyte abnormalities or heart disease.
What this interaction means in plain words
Azithromycin and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Vorinostat belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check and correct potassium and magnesium and obtain an ECG before and during combined use. Consider a non-QT-prolonging antibiotic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Azithromycin with Vorinostat?
MediHelp rates the interaction as moderate. Azithromycin and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat and azithromycin can each prolong the QT interval, so combination may increase the risk of serious ventricular arrhythmia, especially in patients with electrolyte abnormalities or heart disease.
How serious is the interaction between Azithromycin and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium and obtain an ECG before and during combined use. Consider a non-QT-prolonging antibiotic if feasible.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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