Drug interactions
Aztreonam + Chloramphenicol
Severity: Minor
Aztreonam and Chloramphenicol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol is bacteriostatic and may blunt the bactericidal activity of beta-lactams such as aztreonam, which depend on actively growing bacteria. Clinical significance is uncertain and mostly derived from in vitro data and theory.
What this interaction means in plain words
Aztreonam and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aztreonam belongs to Anti Bacterial; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Pharmacodynamic antagonism: inhibition of bacterial protein synthesis reduces cell growth and thus beta-lactam killing.
What to do
Avoid combining a bacteriostatic agent with aztreonam when rapid bactericidal activity is needed, such as in severe sepsis. If both are required, monitor clinical response closely.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aztreonam
- Aztreonam + Cefoxitin Moderate
- Aztreonam + Cholera vaccine Moderate
- Aztreonam + Microbiota Moderate
- Aztreonam + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Aztreonam + Typhoid vaccine live Moderate
- Amikacin + Aztreonam Minor
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Aztreonam with Chloramphenicol?
MediHelp rates the interaction as minor. Aztreonam and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol is bacteriostatic and may blunt the bactericidal activity of beta-lactams such as aztreonam, which depend on actively growing bacteria. Clinical significance is uncertain and mostly derived from in vitro data and theory.
How serious is the interaction between Aztreonam and Chloramphenicol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining a bacteriostatic agent with aztreonam when rapid bactericidal activity is needed, such as in severe sepsis. If both are required, monitor clinical response closely.
What other medicines interact with Aztreonam?
MediHelp also lists interactions of Aztreonam with, for example, Cefoxitin, Cholera vaccine, Microbiota. The full list is on the Aztreonam page.
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