Drug interactions
Aztreonam + Probenecid
Severity: Minor
Aztreonam and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces tubular secretion of aztreonam and modestly raises its serum levels. The change is small and rarely requires intervention.
What this interaction means in plain words
Aztreonam and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aztreonam belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits renal organic anion transporters involved in tubular secretion of aztreonam.
What to do
No dose adjustment is usually needed; be aware of higher exposure in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aztreonam and Probenecid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Aztreonam
- Aztreonam + Cefoxitin Moderate
- Aztreonam + Cholera vaccine Moderate
- Aztreonam + Microbiota Moderate
- Aztreonam + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Aztreonam + Typhoid vaccine live Moderate
- Amikacin + Aztreonam Minor
Frequently asked questions
Can I take Aztreonam with Probenecid?
MediHelp rates the interaction as minor. Aztreonam and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid reduces tubular secretion of aztreonam and modestly raises its serum levels. The change is small and rarely requires intervention.
How serious is the interaction between Aztreonam and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; be aware of higher exposure in patients with renal impairment.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
