Drug interactions
Baclofen + Clobazam
Severity: Moderate
Baclofen and Clobazam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS, and together they can cause marked sedation, ataxia, weakness and respiratory depression. Benzodiazepine labeling warns about combined use with other CNS depressants.
What this interaction means in plain words
Baclofen and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Clobazam belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation by clobazam and GABA-B agonism by baclofen.
What to do
Use the lowest effective doses and monitor sedation, coordination and respiratory status, especially at initiation and dose changes. Avoid adding alcohol or other depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Baclofen with Clobazam?
MediHelp rates the interaction as moderate. Baclofen and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the CNS, and together they can cause marked sedation, ataxia, weakness and respiratory depression. Benzodiazepine labeling warns about combined use with other CNS depressants.
How serious is the interaction between Baclofen and Clobazam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, coordination and respiratory status, especially at initiation and dose changes. Avoid adding alcohol or other depressants.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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