Drug interactions
Baclofen + Clomipramine
Severity: Moderate
Baclofen and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a sedating tricyclic antidepressant. With baclofen, sedation, hypotension and muscle weakness may be increased, and both drugs can lower the seizure threshold.
What this interaction means in plain words
Baclofen and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Clomipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression, with tricyclic antihistaminic and anticholinergic effects added to baclofen's GABA-B activity.
What to do
Monitor for oversedation, confusion, hypotension and falls, particularly in the elderly. Adjust doses or avoid in patients with seizure history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Baclofen with Clomipramine?
MediHelp rates the interaction as moderate. Baclofen and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is a sedating tricyclic antidepressant. With baclofen, sedation, hypotension and muscle weakness may be increased, and both drugs can lower the seizure threshold.
How serious is the interaction between Baclofen and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, confusion, hypotension and falls, particularly in the elderly. Adjust doses or avoid in patients with seizure history.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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