Drug interactions
Baclofen + Clorazepate
Severity: Moderate
Baclofen and Clorazepate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clorazepate is a long-acting benzodiazepine with sedative effects. With baclofen it may produce excessive drowsiness, weakness, ataxia and potentially respiratory depression.
What this interaction means in plain words
Baclofen and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Clorazepate belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A and GABA-B receptor pathways.
What to do
Use the lowest effective doses and monitor for oversedation and falls. Counsel about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Baclofen and Clorazepate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Baclofen
Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Baclofen with Clorazepate?
MediHelp rates the interaction as moderate. Baclofen and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clorazepate is a long-acting benzodiazepine with sedative effects. With baclofen it may produce excessive drowsiness, weakness, ataxia and potentially respiratory depression.
How serious is the interaction between Baclofen and Clorazepate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and falls. Counsel about driving and alcohol.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
