Drug interactions
Baclofen + Hydromorphone
Severity: Moderate
Baclofen and Hydromorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baclofen and hydromorphone both depress the CNS, so combined use increases drowsiness, dizziness, weakness and respiratory depression. The risk is higher in older patients, those with renal impairment and with higher doses.
What this interaction means in plain words
Baclofen and Hydromorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Hydromorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression via opioid receptor agonism and GABA-B agonism.
What to do
Use the lowest effective doses and titrate slowly. Monitor sedation and breathing, and reduce baclofen in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Baclofen and Hydromorphone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Hydromorphone?
MediHelp rates the interaction as moderate. Baclofen and Hydromorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Baclofen and hydromorphone both depress the CNS, so combined use increases drowsiness, dizziness, weakness and respiratory depression. The risk is higher in older patients, those with renal impairment and with higher doses.
How serious is the interaction between Baclofen and Hydromorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and titrate slowly. Monitor sedation and breathing, and reduce baclofen in renal impairment.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
