Drug interactions
Baclofen + Hydroxyzine
Severity: Moderate
Baclofen and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so combined use can lead to marked drowsiness, dizziness and reduced alertness. Older adults are at particular risk of falls and confusion.
What this interaction means in plain words
Baclofen and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Hydroxyzine belongs to Respiratory.
Why it happens
Additive CNS depression from GABA-B agonism and sedating H1-antihistamine effects.
What to do
Warn patients about sedation and driving. Use the lowest effective doses and consider a less sedating alternative in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Baclofen with Hydroxyzine?
MediHelp rates the interaction as moderate. Baclofen and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so combined use can lead to marked drowsiness, dizziness and reduced alertness. Older adults are at particular risk of falls and confusion.
How serious is the interaction between Baclofen and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about sedation and driving. Use the lowest effective doses and consider a less sedating alternative in older adults.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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