Drug interactions
Baclofen + Iloperidone
Severity: Moderate
Baclofen and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is an atypical antipsychotic that commonly causes sedation and orthostatic hypotension, and baclofen adds further CNS depression and can lower blood pressure. The combination may increase drowsiness, dizziness and the risk of falls.
What this interaction means in plain words
Baclofen and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects, with additional alpha-1 adrenergic blockade from iloperidone contributing to hypotension.
What to do
Monitor for sedation and orthostatic symptoms, particularly during iloperidone titration or baclofen dose increases. Reduce one dose if daytime impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Baclofen with Iloperidone?
MediHelp rates the interaction as moderate. Baclofen and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is an atypical antipsychotic that commonly causes sedation and orthostatic hypotension, and baclofen adds further CNS depression and can lower blood pressure. The combination may increase drowsiness, dizziness and the risk of falls.
How serious is the interaction between Baclofen and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic symptoms, particularly during iloperidone titration or baclofen dose increases. Reduce one dose if daytime impairment occurs.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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