Drug interactions
Baclofen + Lasmiditan
Severity: Moderate
Baclofen and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes dizziness, somnolence and cognitive slowing, and baclofen can cause the same effects. Used together they may produce more marked sedation and impaired alertness, and the combination has not been formally studied.
What this interaction means in plain words
Baclofen and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive CNS depressant and sedative effects of two centrally acting drugs.
What to do
Warn patients not to drive or use machinery for at least 8 hours after a lasmiditan dose. Monitor for excessive drowsiness and consider a lower baclofen dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Baclofen with Lasmiditan?
MediHelp rates the interaction as moderate. Baclofen and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes dizziness, somnolence and cognitive slowing, and baclofen can cause the same effects. Used together they may produce more marked sedation and impaired alertness, and the combination has not been formally studied.
How serious is the interaction between Baclofen and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients not to drive or use machinery for at least 8 hours after a lasmiditan dose. Monitor for excessive drowsiness and consider a lower baclofen dose if needed.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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