Drug interactions
Baclofen + Lurasidone
Severity: Moderate
Baclofen and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone can cause somnolence and baclofen is sedating, so combined use may increase drowsiness, dizziness and psychomotor impairment. The effect is pharmacodynamic and generally manageable.
What this interaction means in plain words
Baclofen and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-B agonism and antipsychotic receptor blockade.
What to do
Monitor for sedation and falls, particularly after dose increases. Advise caution with driving and machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Baclofen with Lurasidone?
MediHelp rates the interaction as moderate. Baclofen and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone can cause somnolence and baclofen is sedating, so combined use may increase drowsiness, dizziness and psychomotor impairment. The effect is pharmacodynamic and generally manageable.
How serious is the interaction between Baclofen and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and falls, particularly after dose increases. Advise caution with driving and machinery.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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