Drug interactions
Baclofen + Meperidine
Severity: Moderate
Baclofen and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baclofen and meperidine both depress the CNS, so combined use can cause marked drowsiness, weakness, hypotension and respiratory depression. The effect is more pronounced in older or renally impaired patients because baclofen accumulates.
What this interaction means in plain words
Baclofen and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Meperidine belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression via GABA-B agonism and opioid receptor activation.
What to do
Use the lowest effective doses and monitor sedation and respiratory rate, especially at initiation. Reduce the baclofen dose in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Meperidine?
MediHelp rates the interaction as moderate. Baclofen and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Baclofen and meperidine both depress the CNS, so combined use can cause marked drowsiness, weakness, hypotension and respiratory depression. The effect is more pronounced in older or renally impaired patients because baclofen accumulates.
How serious is the interaction between Baclofen and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate, especially at initiation. Reduce the baclofen dose in renal impairment.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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