Drug interactions
Baclofen + Perphenazine
Severity: Moderate
Baclofen and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is a phenothiazine antipsychotic and with baclofen may cause additive drowsiness, dizziness and impaired coordination. Seizure threshold may also be lowered.
What this interaction means in plain words
Baclofen and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-B agonism and dopamine, histamine and adrenergic receptor blockade.
What to do
Monitor for oversedation, confusion and falls, and reduce doses if needed. Avoid abrupt discontinuation of baclofen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Baclofen with Perphenazine?
MediHelp rates the interaction as moderate. Baclofen and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine is a phenothiazine antipsychotic and with baclofen may cause additive drowsiness, dizziness and impaired coordination. Seizure threshold may also be lowered.
How serious is the interaction between Baclofen and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, confusion and falls, and reduce doses if needed. Avoid abrupt discontinuation of baclofen.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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