Drug interactions
Baclofen + Ziconotide
Severity: Moderate
Baclofen and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide causes dose-related cognitive impairment, confusion, dizziness and reduced alertness, which can be worsened by other CNS depressants including baclofen. This is relevant because both drugs are commonly given intrathecally.
What this interaction means in plain words
Baclofen and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depression and cognitive impairment; ziconotide blocks N-type calcium channels while baclofen acts at GABA-B receptors.
What to do
Monitor mental status and level of consciousness, and reduce the ziconotide or baclofen dose or discontinue ziconotide if cognitive impairment or sedation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Baclofen with Ziconotide?
MediHelp rates the interaction as moderate. Baclofen and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide causes dose-related cognitive impairment, confusion, dizziness and reduced alertness, which can be worsened by other CNS depressants including baclofen. This is relevant because both drugs are commonly given intrathecally.
How serious is the interaction between Baclofen and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental status and level of consciousness, and reduce the ziconotide or baclofen dose or discontinue ziconotide if cognitive impairment or sedation develops.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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