Drug interactions
Baricitinib + Hydrochlorothiazide-irbesartan
Severity: Minor
Baricitinib and Hydrochlorothiazide-irbesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baricitinib is eliminated partly through renal OAT3 transport, and irbesartan has weak OAT3 inhibitory activity. Any rise in baricitinib exposure is expected to be small and is much less than with strong inhibitors such as probenecid.
What this interaction means in plain words
Baricitinib and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Baricitinib belongs to Musculoskeletal; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Possible weak inhibition of OAT3-mediated renal secretion of baricitinib.
What to do
No dose adjustment is generally required; monitor for baricitinib adverse effects such as infection and cytopenias as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as minor. Baricitinib and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Baricitinib is eliminated partly through renal OAT3 transport, and irbesartan has weak OAT3 inhibitory activity. Any rise in baricitinib exposure is expected to be small and is much less than with strong inhibitors such as probenecid.
How serious is the interaction between Baricitinib and Hydrochlorothiazide-irbesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required; monitor for baricitinib adverse effects such as infection and cytopenias as usual.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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