Drug interactions
Baricitinib + Infliximab
Severity: Major
Baricitinib and Infliximab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baricitinib should not be combined with biologic DMARDs such as infliximab because of additive immunosuppression. This raises the risk of serious infection, including opportunistic and reactivated infections.
What this interaction means in plain words
Baricitinib and Infliximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Baricitinib belongs to Musculoskeletal; Infliximab belongs to Musculoskeletal.
Why it happens
Additive immunosuppression from JAK inhibition and TNF-alpha blockade.
What to do
Avoid concurrent use; stop one agent before starting the other, following labeling and clinical judgment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Infliximab?
MediHelp rates the interaction as major. Baricitinib and Infliximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Baricitinib should not be combined with biologic DMARDs such as infliximab because of additive immunosuppression. This raises the risk of serious infection, including opportunistic and reactivated infections.
How serious is the interaction between Baricitinib and Infliximab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; stop one agent before starting the other, following labeling and clinical judgment.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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