Drug interactions
Baricitinib + Pretomanid
Severity: Minor
Baricitinib and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits OAT3 in vitro, and baricitinib is cleared by renal transporters including OAT3. Exposure to baricitinib may increase, though clinical data are lacking.
What this interaction means in plain words
Baricitinib and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Baricitinib belongs to Musculoskeletal; Pretomanid belongs to Anti Bacterial.
Why it happens
Inhibition of OAT3-mediated renal secretion of baricitinib by pretomanid.
What to do
Monitor for baricitinib adverse effects such as infection and cytopenias. Consider dose reduction if toxicity emerges.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Baricitinib with Pretomanid?
MediHelp rates the interaction as minor. Baricitinib and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid inhibits OAT3 in vitro, and baricitinib is cleared by renal transporters including OAT3. Exposure to baricitinib may increase, though clinical data are lacking.
How serious is the interaction between Baricitinib and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for baricitinib adverse effects such as infection and cytopenias. Consider dose reduction if toxicity emerges.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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