Drug interactions
Basiliximab + Golimumab
Severity: Major
Basiliximab and Golimumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Golimumab blocks TNF-alpha and basiliximab blocks the IL-2 receptor on activated T cells, so using them together produces broader immune suppression. This raises the risk of serious bacterial, fungal, viral and opportunistic infections.
What this interaction means in plain words
Basiliximab and Golimumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Basiliximab belongs to Miscellaneous; Golimumab belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic immunosuppression through TNF blockade and IL-2 receptor antagonism.
What to do
Avoid routine combination unless clearly justified, for example in a transplant setting under specialist direction. If used together, monitor closely for infection and stop golimumab if a serious infection develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Basiliximab and Golimumab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Basiliximab
- Basiliximab + Bcg vaccine live Contraindicated
- Basiliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine live Contraindicated
- Basiliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Basiliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Basiliximab with Golimumab?
MediHelp rates the interaction as major. Basiliximab and Golimumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Golimumab blocks TNF-alpha and basiliximab blocks the IL-2 receptor on activated T cells, so using them together produces broader immune suppression. This raises the risk of serious bacterial, fungal, viral and opportunistic infections.
How serious is the interaction between Basiliximab and Golimumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination unless clearly justified, for example in a transplant setting under specialist direction. If used together, monitor closely for infection and stop golimumab if a serious infection develops.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
