Drug interactions
Basiliximab + Ocrelizumab
Severity: Moderate
Basiliximab and Ocrelizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ocrelizumab depletes B cells and basiliximab blocks T-cell activation, so using both increases overall immunosuppression. Patients are at higher risk of serious bacterial, viral and opportunistic infections.
What this interaction means in plain words
Basiliximab and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Basiliximab belongs to Miscellaneous; Ocrelizumab belongs to Central Nervous System.
Why it happens
Additive immunosuppression from CD20-mediated B-cell depletion and IL-2 receptor blockade on activated T cells.
What to do
Monitor for signs of infection throughout and after co-treatment, and consider the timing of ocrelizumab doses around transplant induction. Use standard infection prophylaxis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Other interactions of Basiliximab
- Basiliximab + Bcg vaccine live Contraindicated
- Basiliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine live Contraindicated
- Basiliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Basiliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Basiliximab with Ocrelizumab?
MediHelp rates the interaction as moderate. Basiliximab and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ocrelizumab depletes B cells and basiliximab blocks T-cell activation, so using both increases overall immunosuppression. Patients are at higher risk of serious bacterial, viral and opportunistic infections.
How serious is the interaction between Basiliximab and Ocrelizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection throughout and after co-treatment, and consider the timing of ocrelizumab doses around transplant induction. Use standard infection prophylaxis.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Ocrelizumab page.
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