Drug interactions
Bazedoxifene-conjugated estrogens + Bosentan
Severity: Moderate
Bazedoxifene-conjugated estrogens and Bosentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and may lower bazedoxifene and estrogen concentrations. This could reduce menopausal symptom control and endometrial protection.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Bosentan belongs to Miscellaneous.
Why it happens
Bosentan induces CYP3A4, increasing hepatic and intestinal metabolism of the estrogen components and bazedoxifene.
What to do
Monitor for loss of efficacy and for abnormal uterine bleeding. Consider a different therapy if symptoms are not controlled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Bosentan?
MediHelp rates the interaction as moderate. Bazedoxifene-conjugated estrogens and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan induces CYP3A4 and may lower bazedoxifene and estrogen concentrations. This could reduce menopausal symptom control and endometrial protection.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Bosentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy and for abnormal uterine bleeding. Consider a different therapy if symptoms are not controlled.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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