Drug interactions
Bazedoxifene-conjugated estrogens + Clarithromycin
Severity: Moderate
Bazedoxifene-conjugated estrogens and Clarithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin is a strong CYP3A4 inhibitor and can increase exposure to the estrogens and bazedoxifene. Higher levels may increase estrogen-related adverse effects, including thromboembolic risk and endometrial stimulation.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Clarithromycin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated metabolism by clarithromycin reduces clearance of estrogens and bazedoxifene.
What to do
Consider an alternative antibiotic such as azithromycin when feasible. If clarithromycin is used for a short course, monitor for estrogen excess effects such as breast tenderness, nausea and edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Clarithromycin?
MediHelp rates the interaction as moderate. Bazedoxifene-conjugated estrogens and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin is a strong CYP3A4 inhibitor and can increase exposure to the estrogens and bazedoxifene. Higher levels may increase estrogen-related adverse effects, including thromboembolic risk and endometrial stimulation.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic such as azithromycin when feasible. If clarithromycin is used for a short course, monitor for estrogen excess effects such as breast tenderness, nausea and edema.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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