Drug interactions
Bazedoxifene-conjugated estrogens + Fluconazole
Severity: Moderate
Bazedoxifene-conjugated estrogens and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP3A4 and may raise exposure to the estrogen and bazedoxifene components. Higher exposure could increase estrogen-related adverse effects such as breast tenderness, fluid retention or endometrial stimulation.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated metabolism by fluconazole reduces clearance of the estrogens and bazedoxifene.
What to do
Monitor for estrogenic adverse effects such as breast tenderness, edema and abnormal bleeding during fluconazole therapy. Reassess the hormone dose if symptoms occur or if fluconazole is used long term.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Fluconazole?
MediHelp rates the interaction as moderate. Bazedoxifene-conjugated estrogens and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP3A4 and may raise exposure to the estrogen and bazedoxifene components. Higher exposure could increase estrogen-related adverse effects such as breast tenderness, fluid retention or endometrial stimulation.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects such as breast tenderness, edema and abnormal bleeding during fluconazole therapy. Reassess the hormone dose if symptoms occur or if fluconazole is used long term.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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