Drug interactions
Bazedoxifene / conjugated estrogens + Fosfomycin
Severity: Minor
Bazedoxifene / conjugated estrogens and Fosfomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some antibiotics have been proposed to lower oral estrogen levels by disrupting gut flora involved in enterohepatic recirculation. For menopausal hormone therapy this is unlikely to matter clinically, and fosfomycin is not an established cause.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Fosfomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction in enterohepatic recycling of estrogens due to altered gut flora.
What to do
No routine action is needed. Advise the patient to report breakthrough bleeding or return of menopausal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosfomycin
- Cholera vaccine + Fosfomycin Moderate
- Fosfomycin + Metoclopramide Moderate
- Fosfomycin + Metoclopramide intranasal Moderate
- Fosfomycin + Microbiota Moderate
- Fosfomycin + Typhoid vaccine live Moderate
- Bcg vaccine live + Fosfomycin Minor
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Fosfomycin?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Fosfomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Some antibiotics have been proposed to lower oral estrogen levels by disrupting gut flora involved in enterohepatic recirculation. For menopausal hormone therapy this is unlikely to matter clinically, and fosfomycin is not an established cause.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Fosfomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Advise the patient to report breakthrough bleeding or return of menopausal symptoms.
What other medicines interact with Fosfomycin?
MediHelp also lists interactions of Fosfomycin with, for example, Cholera vaccine, Metoclopramide, Metoclopramide intranasal. The full list is on the Fosfomycin page.
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