Drug interactions
Fosfomycin + Microbiota
Severity: Moderate
Fosfomycin and Microbiota: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral fecal microbiota products contain live bacterial spores meant to recolonize the gut. Systemic or luminal antibacterials may kill or suppress these organisms and reduce the therapy's effectiveness.
What this interaction means in plain words
Fosfomycin and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity reduces viability and engraftment of the live microbiota product.
What to do
Complete the antibiotic course and allow a washout of 2 to 4 days before starting oral microbiota, as labeled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosfomycin
Frequently asked questions
Can I take Fosfomycin with Microbiota?
MediHelp rates the interaction as moderate. Fosfomycin and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral fecal microbiota products contain live bacterial spores meant to recolonize the gut. Systemic or luminal antibacterials may kill or suppress these organisms and reduce the therapy's effectiveness.
How serious is the interaction between Fosfomycin and Microbiota?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the antibiotic course and allow a washout of 2 to 4 days before starting oral microbiota, as labeled.
What other medicines interact with Fosfomycin?
MediHelp also lists interactions of Fosfomycin with, for example, Cholera vaccine, Metoclopramide, Metoclopramide intranasal. The full list is on the Fosfomycin page.
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