Drug interactions
Fosfomycin + Metoclopramide intranasal
Severity: Moderate
Fosfomycin and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide increases gastric emptying and intestinal motility, which can lower the oral absorption of oral fosfomycin. This may reduce urinary concentrations and the therapeutic effect in urinary tract infection.
What this interaction means in plain words
Fosfomycin and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Accelerated gastrointestinal transit reduces absorption of oral fosfomycin.
What to do
Avoid combining where possible, or consider an alternative antiemetic. Monitor for treatment failure of the urinary infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosfomycin
- Cholera vaccine + Fosfomycin Moderate
- Fosfomycin + Metoclopramide Moderate
- Fosfomycin + Microbiota Moderate
- Fosfomycin + Typhoid vaccine live Moderate
- Bazedoxifene / conjugated estrogens + Fosfomycin Minor
- Bcg vaccine live + Fosfomycin Minor
Frequently asked questions
Can I take Fosfomycin with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Fosfomycin and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide increases gastric emptying and intestinal motility, which can lower the oral absorption of oral fosfomycin. This may reduce urinary concentrations and the therapeutic effect in urinary tract infection.
How serious is the interaction between Fosfomycin and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or consider an alternative antiemetic. Monitor for treatment failure of the urinary infection.
What other medicines interact with Fosfomycin?
MediHelp also lists interactions of Fosfomycin with, for example, Cholera vaccine, Metoclopramide, Microbiota. The full list is on the Fosfomycin page.
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