Drug interactions
Fosfomycin + Typhoid vaccine live
Severity: Moderate
Fosfomycin and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi in the gut. Fosfomycin has broad gram-negative activity and may reduce vaccine viability, although oral fosfomycin is used mainly as a single urinary dose.
What this interaction means in plain words
Fosfomycin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity may inhibit the live attenuated Salmonella strain, reducing immunogenicity.
What to do
Give live oral typhoid vaccine at least 3 days after the last fosfomycin dose, or vaccinate beforehand. The inactivated Vi vaccine is an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosfomycin
Frequently asked questions
Can I take Fosfomycin with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Fosfomycin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi in the gut. Fosfomycin has broad gram-negative activity and may reduce vaccine viability, although oral fosfomycin is used mainly as a single urinary dose.
How serious is the interaction between Fosfomycin and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give live oral typhoid vaccine at least 3 days after the last fosfomycin dose, or vaccinate beforehand. The inactivated Vi vaccine is an alternative.
What other medicines interact with Fosfomycin?
MediHelp also lists interactions of Fosfomycin with, for example, Cholera vaccine, Metoclopramide, Metoclopramide intranasal. The full list is on the Fosfomycin page.
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