Drug interactions
Cholera vaccine + Fosfomycin
Severity: Moderate
Cholera vaccine and Fosfomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral cholera vaccine contains live attenuated bacteria that must multiply in the gut to induce immunity. An antibiotic active against the vaccine strain may reduce its replication and weaken the immune response.
What this interaction means in plain words
Cholera vaccine and Fosfomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live attenuated vaccine strain reduces vaccine colonization and immunogenicity.
What to do
Do not give the cholera vaccine within 14 days after oral or parenteral antibiotics; delay vaccination until after the antibiotic course is finished.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosfomycin
Frequently asked questions
Can I take Cholera vaccine with Fosfomycin?
MediHelp rates the interaction as moderate. Cholera vaccine and Fosfomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral cholera vaccine contains live attenuated bacteria that must multiply in the gut to induce immunity. An antibiotic active against the vaccine strain may reduce its replication and weaken the immune response.
How serious is the interaction between Cholera vaccine and Fosfomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the cholera vaccine within 14 days after oral or parenteral antibiotics; delay vaccination until after the antibiotic course is finished.
What other medicines interact with Fosfomycin?
MediHelp also lists interactions of Fosfomycin with, for example, Metoclopramide, Metoclopramide intranasal, Microbiota. The full list is on the Fosfomycin page.
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