Drug interactions
Fosfomycin + Metoclopramide
Severity: Moderate
Fosfomycin and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide may reduce the oral absorption of fosfomycin, which could lower urinary concentrations. This could lead to reduced efficacy in urinary tract infection.
What this interaction means in plain words
Fosfomycin and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosfomycin belongs to Anti Bacterial; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Increased GI motility reduces the time for fosfomycin absorption.
What to do
Monitor for lack of clinical response to fosfomycin. Consider an alternative to metoclopramide or another antibiotic if symptoms persist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Fosfomycin
Frequently asked questions
Can I take Fosfomycin with Metoclopramide?
MediHelp rates the interaction as moderate. Fosfomycin and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide may reduce the oral absorption of fosfomycin, which could lower urinary concentrations. This could lead to reduced efficacy in urinary tract infection.
How serious is the interaction between Fosfomycin and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lack of clinical response to fosfomycin. Consider an alternative to metoclopramide or another antibiotic if symptoms persist.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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