Drug interactions
Bazedoxifene / conjugated estrogens + Posaconazole
Severity: Moderate
Bazedoxifene / conjugated estrogens and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase exposure to bazedoxifene and estrogens through CYP3A4 inhibition. This may heighten estrogenic effects and thromboembolic or endometrial risk.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Posaconazole inhibits CYP3A4-mediated metabolism of estrogens and bazedoxifene.
What to do
Monitor for estrogen excess such as breast tenderness, bleeding and thromboembolic symptoms. Reassess the need for the combination during extended azole therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Posaconazole?
MediHelp rates the interaction as moderate. Bazedoxifene / conjugated estrogens and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole may increase exposure to bazedoxifene and estrogens through CYP3A4 inhibition. This may heighten estrogenic effects and thromboembolic or endometrial risk.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen excess such as breast tenderness, bleeding and thromboembolic symptoms. Reassess the need for the combination during extended azole therapy.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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