Drug interactions
Bcg vaccine live + Secukinumab
Severity: Major
Bcg vaccine live and Secukinumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secukinumab may reduce the immune response to live vaccines and theoretically allows replication of attenuated organisms. BCG carries a known risk of disseminated infection in immunocompromised people.
What this interaction means in plain words
Bcg vaccine live and Secukinumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Immunomodulation by IL-17A blockade may impair control of live attenuated BCG and reduce vaccine response.
What to do
Give BCG before starting secukinumab where feasible. Avoid BCG during treatment and delay it until after treatment is stopped, taking specialist advice.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secukinumab
- Adenovirus types 4 and 7 live + Secukinumab Major
- Influenza virus vaccine quadrivalent intranasal + Secukinumab Major
- Measles mumps and rubella vaccine live + Secukinumab Major
- Measles mumps and rubella vaccine + Secukinumab Major
- Measles mumps rubella and varicella vaccine live + Secukinumab Major
- Measles vaccine + Secukinumab Major
Frequently asked questions
Can I take Bcg vaccine live with Secukinumab?
MediHelp rates the interaction as major. Bcg vaccine live and Secukinumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Secukinumab may reduce the immune response to live vaccines and theoretically allows replication of attenuated organisms. BCG carries a known risk of disseminated infection in immunocompromised people.
How serious is the interaction between Bcg vaccine live and Secukinumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give BCG before starting secukinumab where feasible. Avoid BCG during treatment and delay it until after treatment is stopped, taking specialist advice.
What other medicines interact with Secukinumab?
MediHelp also lists interactions of Secukinumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Secukinumab page.
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