Drug interactions
Influenza virus vaccine quadrivalent intranasal + Secukinumab
Severity: Major
Influenza virus vaccine quadrivalent intranasal and Secukinumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intranasal influenza vaccine contains live attenuated virus, and secukinumab may lessen the vaccine response or allow more vaccine-strain replication. Evidence of harm is limited, but live vaccines are generally avoided.
What this interaction means in plain words
Influenza virus vaccine quadrivalent intranasal and Secukinumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Immunomodulation by IL-17A blockade may reduce immunogenicity and weaken control of live attenuated virus.
What to do
Use the inactivated injectable influenza vaccine instead of the live intranasal vaccine in patients on secukinumab.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secukinumab
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent intranasal with Secukinumab?
MediHelp rates the interaction as major. Influenza virus vaccine quadrivalent intranasal and Secukinumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The intranasal influenza vaccine contains live attenuated virus, and secukinumab may lessen the vaccine response or allow more vaccine-strain replication. Evidence of harm is limited, but live vaccines are generally avoided.
How serious is the interaction between Influenza virus vaccine quadrivalent intranasal and Secukinumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the inactivated injectable influenza vaccine instead of the live intranasal vaccine in patients on secukinumab.
What other medicines interact with Secukinumab?
MediHelp also lists interactions of Secukinumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Measles mumps and rubella vaccine live. The full list is on the Secukinumab page.
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