Drug interactions
Measles mumps rubella and varicella vaccine live + Secukinumab
Severity: Major
Measles mumps rubella and varicella vaccine live and Secukinumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This vaccine contains four live attenuated viruses, and secukinumab may weaken the response or allow excessive vaccine-virus replication. Evidence is limited, but live vaccines are avoided in patients on biologics.
What this interaction means in plain words
Measles mumps rubella and varicella vaccine live and Secukinumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Immunomodulation by IL-17A blockade may reduce immunogenicity and impair control of live attenuated viruses.
What to do
Complete MMRV immunization before starting secukinumab where possible. Avoid it during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secukinumab
Frequently asked questions
Can I take Measles mumps rubella and varicella vaccine live with Secukinumab?
MediHelp rates the interaction as major. Measles mumps rubella and varicella vaccine live and Secukinumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. This vaccine contains four live attenuated viruses, and secukinumab may weaken the response or allow excessive vaccine-virus replication. Evidence is limited, but live vaccines are avoided in patients on biologics.
How serious is the interaction between Measles mumps rubella and varicella vaccine live and Secukinumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete MMRV immunization before starting secukinumab where possible. Avoid it during treatment.
What other medicines interact with Secukinumab?
MediHelp also lists interactions of Secukinumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Secukinumab page.
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