Drug interactions
Bedaquiline + Budesonide-formoterol
Severity: Moderate
Bedaquiline and Budesonide-formoterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bedaquiline prolongs the QT interval and formoterol can also prolong QTc and lower potassium. Combined use may increase the risk of torsades de pointes, especially with electrolyte disturbance or heart disease.
What this interaction means in plain words
Bedaquiline and Budesonide-formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bedaquiline belongs to Anti Bacterial; Budesonide-formoterol belongs to Respiratory.
Why it happens
Additive QT prolongation, with formoterol-induced hypokalemia further increasing arrhythmia risk.
What to do
Obtain a baseline ECG and repeat it during therapy; keep potassium, magnesium and calcium within normal range and use formoterol at the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Budesonide-formoterol?
MediHelp rates the interaction as moderate. Bedaquiline and Budesonide-formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bedaquiline prolongs the QT interval and formoterol can also prolong QTc and lower potassium. Combined use may increase the risk of torsades de pointes, especially with electrolyte disturbance or heart disease.
How serious is the interaction between Bedaquiline and Budesonide-formoterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it during therapy; keep potassium, magnesium and calcium within normal range and use formoterol at the lowest effective dose.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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