Drug interactions
Bedaquiline + Fluticasone-vilanterol
Severity: Moderate
Bedaquiline and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bedaquiline prolongs the QT interval and vilanterol may add to cardiac repolarization effects and lower potassium. Together they may raise the risk of torsade de pointes, especially alongside other QT-prolonging tuberculosis drugs.
What this interaction means in plain words
Bedaquiline and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bedaquiline belongs to Anti Bacterial; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation and beta2-agonist-related hypokalemia and tachycardia.
What to do
Perform serial ECG monitoring during bedaquiline therapy and keep potassium, magnesium and calcium normal. Consider whether a non-LABA option is suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Bedaquiline and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bedaquiline prolongs the QT interval and vilanterol may add to cardiac repolarization effects and lower potassium. Together they may raise the risk of torsade de pointes, especially alongside other QT-prolonging tuberculosis drugs.
How serious is the interaction between Bedaquiline and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform serial ECG monitoring during bedaquiline therapy and keep potassium, magnesium and calcium normal. Consider whether a non-LABA option is suitable.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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