Drug interactions
Bedaquiline + Imatinib
Severity: Moderate
Bedaquiline and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bedaquiline is metabolized by CYP3A4, and imatinib is a moderate CYP3A4 inhibitor. Bedaquiline exposure may increase, and both drugs can prolong the QT interval. This raises the risk of QT-related arrhythmia.
What this interaction means in plain words
Bedaquiline and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bedaquiline belongs to Anti Bacterial; Imatinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by imatinib raises bedaquiline levels, combined with additive QT prolongation.
What to do
Obtain a baseline ECG and monitor periodically, with electrolytes. Stop or reconsider therapy if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Imatinib?
MediHelp rates the interaction as moderate. Bedaquiline and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bedaquiline is metabolized by CYP3A4, and imatinib is a moderate CYP3A4 inhibitor. Bedaquiline exposure may increase, and both drugs can prolong the QT interval. This raises the risk of QT-related arrhythmia.
How serious is the interaction between Bedaquiline and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor periodically, with electrolytes. Stop or reconsider therapy if the QTc becomes markedly prolonged.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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