Drug interactions
Bedaquiline + Ipratropium-salbutamol
Severity: Moderate
Bedaquiline and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bedaquiline prolongs the QT interval, and salbutamol may add to arrhythmic risk through tachycardia and hypokalemia. The concern is greater with high-dose or frequent salbutamol use and electrolyte disturbance.
What this interaction means in plain words
Bedaquiline and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bedaquiline belongs to Anti Bacterial; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-2-agonist-induced hypokalemia.
What to do
Monitor ECG and keep potassium, magnesium and calcium within normal ranges during bedaquiline therapy. Avoid excessive salbutamol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Bedaquiline and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bedaquiline prolongs the QT interval, and salbutamol may add to arrhythmic risk through tachycardia and hypokalemia. The concern is greater with high-dose or frequent salbutamol use and electrolyte disturbance.
How serious is the interaction between Bedaquiline and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and keep potassium, magnesium and calcium within normal ranges during bedaquiline therapy. Avoid excessive salbutamol use.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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