Drug interactions
Bedaquiline + Lapatinib
Severity: Major
Bedaquiline and Lapatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents prolong the QTc interval, and their combination may increase the chance of serious ventricular arrhythmias such as torsades de pointes. The risk is greater with hypokalemia, hypomagnesemia, bradycardia or other QT-prolonging drugs.
What this interaction means in plain words
Bedaquiline and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bedaquiline belongs to Anti Bacterial; Lapatinib belongs to Oncology.
Why it happens
Additive delay of ventricular repolarization from effects on cardiac ion channels.
What to do
Perform ECG at baseline and regularly during co-therapy, and correct electrolytes before and during treatment. Stop one of the drugs if QTc exceeds 500 ms or syncope or palpitations occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Lapatinib?
MediHelp rates the interaction as major. Bedaquiline and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents prolong the QTc interval, and their combination may increase the chance of serious ventricular arrhythmias such as torsades de pointes. The risk is greater with hypokalemia, hypomagnesemia, bradycardia or other QT-prolonging drugs.
How serious is the interaction between Bedaquiline and Lapatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG at baseline and regularly during co-therapy, and correct electrolytes before and during treatment. Stop one of the drugs if QTc exceeds 500 ms or syncope or palpitations occur.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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