Drug interactions
Bedaquiline + Mifepristone
Severity: Major
Bedaquiline and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and mifepristone also raises bedaquiline concentrations through CYP3A4 inhibition. The combined effect increases the risk of QT prolongation and serious ventricular arrhythmias.
What this interaction means in plain words
Bedaquiline and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bedaquiline belongs to Anti Bacterial; Mifepristone belongs to Endocrine.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition by mifepristone that increases bedaquiline exposure.
What to do
Avoid the combination if possible, and do not continue strong CYP3A4 inhibitors with bedaquiline beyond 14 days unless benefit outweighs risk. If used, obtain ECGs at baseline and regularly and correct potassium, magnesium and calcium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bedaquiline and Mifepristone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Mifepristone?
MediHelp rates the interaction as major. Bedaquiline and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and mifepristone also raises bedaquiline concentrations through CYP3A4 inhibition. The combined effect increases the risk of QT prolongation and serious ventricular arrhythmias.
How serious is the interaction between Bedaquiline and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, and do not continue strong CYP3A4 inhibitors with bedaquiline beyond 14 days unless benefit outweighs risk. If used, obtain ECGs at baseline and regularly and correct potassium, magnesium and calcium.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
