Drug interactions
Bedaquiline + Nicardipine
Severity: Moderate
Bedaquiline and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may modestly raise bedaquiline exposure through CYP3A4 inhibition. Higher bedaquiline levels may increase QT prolongation and hepatotoxicity risk.
What this interaction means in plain words
Bedaquiline and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bedaquiline belongs to Anti Bacterial; Nicardipine belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by nicardipine reduces bedaquiline clearance.
What to do
Monitor ECG for QTc prolongation and liver function during co-treatment. Correct electrolytes and review other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bedaquiline and Nicardipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nicardipine
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Nicardipine?
MediHelp rates the interaction as moderate. Bedaquiline and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine may modestly raise bedaquiline exposure through CYP3A4 inhibition. Higher bedaquiline levels may increase QT prolongation and hepatotoxicity risk.
How serious is the interaction between Bedaquiline and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG for QTc prolongation and liver function during co-treatment. Correct electrolytes and review other QT-prolonging drugs.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
