Drug interactions
Bedaquiline + Umeclidinium-vilanterol
Severity: Moderate
Bedaquiline and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bedaquiline prolongs the QT interval, and vilanterol, a long-acting beta-2 agonist, can also affect repolarization and raise heart rate. Together they may add to the risk of QT prolongation and ventricular arrhythmias, particularly if potassium is low.
What this interaction means in plain words
Bedaquiline and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bedaquiline belongs to Anti Bacterial; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization (QT prolongation) and beta-adrenergic cardiac stimulation.
What to do
Obtain a baseline ECG and repeat it during bedaquiline therapy, and correct potassium, magnesium and calcium abnormalities. Stop or reconsider the combination if the QTc becomes markedly prolonged or the patient has arrhythmia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Bedaquiline and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bedaquiline prolongs the QT interval, and vilanterol, a long-acting beta-2 agonist, can also affect repolarization and raise heart rate. Together they may add to the risk of QT prolongation and ventricular arrhythmias, particularly if potassium is low.
How serious is the interaction between Bedaquiline and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it during bedaquiline therapy, and correct potassium, magnesium and calcium abnormalities. Stop or reconsider the combination if the QTc becomes markedly prolonged or the patient has arrhythmia symptoms.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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