Drug interactions
Belladonna alkaloids + Chlorpromazine
Severity: Moderate
Belladonna alkaloids and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have antimuscarinic activity, so the combination can cause excess anticholinergic effects such as dry mouth, urinary retention, constipation, tachycardia, confusion, and hyperthermia. Oral belladonna alkaloids may also slow gut transit and reduce chlorpromazine absorption.
What this interaction means in plain words
Belladonna alkaloids and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects, with possible reduced oral chlorpromazine absorption.
What to do
Monitor for anticholinergic toxicity and for reduced antipsychotic effect. Avoid the combination in elderly patients or those with glaucoma or urinary obstruction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Belladonna alkaloids with Chlorpromazine?
MediHelp rates the interaction as moderate. Belladonna alkaloids and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have antimuscarinic activity, so the combination can cause excess anticholinergic effects such as dry mouth, urinary retention, constipation, tachycardia, confusion, and hyperthermia. Oral belladonna alkaloids may also slow gut transit and reduce chlorpromazine absorption.
How serious is the interaction between Belladonna alkaloids and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and for reduced antipsychotic effect. Avoid the combination in elderly patients or those with glaucoma or urinary obstruction.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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