Drug interactions
Belladonna alkaloids + Prochlorperazine
Severity: Moderate
Belladonna alkaloids and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna alkaloids are anticholinergic and add to prochlorperazine's antimuscarinic effects, which can cause dry mouth, constipation, urinary retention, tachycardia and confusion. They may also slow gastric emptying and lower oral phenothiazine absorption.
What this interaction means in plain words
Belladonna alkaloids and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects and reduced gastrointestinal motility.
What to do
Monitor for anticholinergic toxicity, particularly in older adults and those with glaucoma or urinary obstruction. Lower the doses if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Belladonna alkaloids with Prochlorperazine?
MediHelp rates the interaction as moderate. Belladonna alkaloids and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna alkaloids are anticholinergic and add to prochlorperazine's antimuscarinic effects, which can cause dry mouth, constipation, urinary retention, tachycardia and confusion. They may also slow gastric emptying and lower oral phenothiazine absorption.
How serious is the interaction between Belladonna alkaloids and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, particularly in older adults and those with glaucoma or urinary obstruction. Lower the doses if adverse effects occur.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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