Drug interactions
Belladonna and opium + Lisdexamfetamine
Severity: Moderate
Belladonna and opium and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opium can cause sedation and respiratory depression, and belladonna adds anticholinergic effects. Amphetamine may mask sedation but does not reverse respiratory depression, and both components can affect heart rate.
What this interaction means in plain words
Belladonna and opium and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS effects with additive cardiovascular and anticholinergic effects; net interaction is not well established.
What to do
Monitor respiratory rate, heart rate and blood pressure. Do not rely on alertness as a marker of opioid safety.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Belladonna and opium with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Belladonna and opium and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opium can cause sedation and respiratory depression, and belladonna adds anticholinergic effects. Amphetamine may mask sedation but does not reverse respiratory depression, and both components can affect heart rate.
How serious is the interaction between Belladonna and opium and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate, heart rate and blood pressure. Do not rely on alertness as a marker of opioid safety.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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